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- First in the World to describe and perform a novel keyhole Minisupraorbital basal trans-isthmus approach to anterior insular lesions
- Successfully Removed largest brain tumor, a Tennis ball sized cm meningioma located in the suprasellar region, ever operated via eyelid
- First in South India to perform DREZOtomy for cancer-related pain
- First in India and South Asia to perform an "Awake" Brain Bypass Surgery for Stroke
- First in India to describe utility of intraoperative CT scan in enhancing precision and surgical safety in Neurosurgery
- First in India and South Asia to do a selective dorsal rhizotomy surgery for upper limb spasticity
- Along with colleagues in Switzerland, pioneered a novel keyhole approach to the tumors located in the lateral ventricle of the brain
- Performed a first of its kind multistage surgery - a hybrid strategy involving high flow brain bypass and endovascular intervention to treat an extremely complex, life-threatening aneurysm in a young patient
- First in the Indian subcontinent to assess serum S100 as a biomarker for diagnosis and prognostication of Intracerebral bleed
- Along with colleagues at CMC Vellore, developed and described a simple tool "Vellore Localizer" for placing the shunt tube accurately
- First in India to commence a trial on Amantidine to assess its efficacy in improving consciousness after traumatic brain injury
- First to develop an Animal model of reversible stroke and first to assess the role of lactate as a neuroprotective agent in India
- Described Shunt anchoring device of ventriculoureteral shunt
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